This article examines the relationship between the tightness-looseness of a culture and the variation of COVID-19 cases and deaths through October 2020. With COVID-19 data retrieved from Our World in Data from 57 countries with tightness-looseness figures, the article found the cultures with high levels of tightness had fewer COVID-19 cases and deaths when compared to countries with high levels of looseness. Results suggest support of the evolutionary game theoretic model proposing that people in tight cultures may cooperate with more urgency when under collective threat than people in loose cultures.